Acrobat Genomics

What We Do

The AcrobaTx™ Engine

A closed-loop system for programmable biology. Each cycle generates proprietary training data, making the next cycle better.

Generate

AI proposes therapeutic candidates

Screen

Parallel testing across designs

Measure

Functional data from living human cells

Steer

Data trains next cycle's AI

AcrobaTx™

Engine

Our People

A multidisciplinary team built to program biology

Founding Team

Nick Hughes, PhD

Co-founder / CEO

Previous Affiliations Stanford Medicine

Muni Nakamura, PhD

Co-founder / CSO

Previous Affiliations Stanford Bioengineering

Grant Goldman, PhD

AI/ML Research Scientist

Previous Affiliations UCSF

Kaitlyn Spees, BS

Senior Research Associate

Previous Affiliations Stanford Medicine

Sourab Kulkarni, MS

Senior Research Associate

Previous Affiliations University of Illinois

Scientific Advisory Board

Le Cong, PhD

Associate Professor of Pathology and Genetics

Monte Winslow, PhD

Associate Professor of Genetics and Pathology

Doug Fowler, PhD

Professor of Genome Sciences

Publications

Peer-reviewed science

From Acrobat Genomics

Computationally guided high-throughput engineering of an anti-CRISPR protein for precise genome editing in human cells

Marsiglia J, Vaalavirta K, Knight E, Nakamura M, Cong L, Hughes NW

Cell Reports Methods · 2024

Selected Publications

Uncovering differential tolerance to deletions versus substitutions with a protein language model

Goldman G, Chati P, Ntranos V

Cell Systems2025

Genome-wide prediction of disease variant effects with a deep protein language model

Brandes N, Goldman G, Wang CH, Ye CJ, Ntranos V

Nature Genetics2023

Machine-learning-optimized Cas12a barcoding enables the recovery of single-cell lineages and transcriptional profiles

Hughes NW, Qu Y, et al.

Molecular Cell2022

Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing

Xu X, Chemparathy A, Zeng L, Kempton HR, Shang S, Nakamura M, Qi LS

Molecular Cell2021

CRISPR technologies for precise epigenome editing

Nakamura M, Gao Y, Dominguez AA, Qi LS

Nature Cell Biology2021

CRISPR-mediated live imaging of genome editing and transcription

Wang H, Nakamura M, et al.

Science2019

Anti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells

Nakamura M, Srinivasan P, et al.

Nature Communications2019

Gene essentiality profiling reveals gene networks and synthetic lethal interactions with oncogenic Ras

Wang T, Yu H, Hughes NW, et al.

Cell2017

Identification and characterization of essential genes in the human genome

Wang T, Birsoy K, Hughes NW, et al.

Science2015

News

Milestones & momentum

April 2026