Acrobat Genomics Publishes Peer-Reviewed Study Showcasing its Protein Engineering Platform

October 28, 2024

We are excited to announce our publication in Cell Reports Methods in Cell Press showcasing how we are advancing the gene editing toolkit using computationally guided high-throughput engineering. To summarize:

1. We used computational and structural guidance to identify engineering hotspots within a small protein that inhibits gene editing activity.

2. Then, we did a deep scan within this hotspot to identify designs that convert the inhibitory protein into a modulator that "dials back" potentially harmful off-target effects while retaining on-target activity.

3. In a single experiment, we tested >10,000 protein designs across millions of human cells, which is one of the largest scans in human cells to date.

4. We found that the final protein product (enAcr-1) is synergistic with pre-existing engineered Cas9 tools and, in theory, could be used to boost the DNA targeting specificity of other CRISPR-based applications.

A huge shoutout to our dedicated (and nimble) team of scientists, advisors, and investors for making this happen! Thanks also to our participation in the NVIDIA Inception program, Illumina for Startups, and support within MBC BioLabs. By leveraging NVIDIA’s and Illumina’s computational and sequencing resources within our plug-and-play laboratory space, we’re engineering the future of genome editing.

Curious about what’s next? Reach out—we have big things in the pipeline that we’d love to share. Let’s take the next leap together!
Read the paper at this link: https://lnkd.in/gXYkSVsT.